Quantitative Estimation of Phthalates from Commercial Bottled Water

IJEP 44(10): 881-888 : Vol. 44 Issue. 10 (October 2024)

Amritha P.S., Veena Vinod and P.B. Harathi*

PSGR Krishnammal College for Women, Department of Zoology, Coimbatore – 641 004, Tamil Nadu, India

Abstract

Phthalates are one of the additives used during plastic manufacturing, which acts as endocrine disruptors. When plastics are exposed to different types of stresses, they have the tendency for phthalates to leach out from the plastic bottles into the water. PAEs are known to cause different disorders in humans of all ages. In this regard, there is a need to study the amount of the PAEs in bottled water. The aim of the study was to determine the concentrations of PAEs in five different commercial bottled waters bought from the local markets and to estimate the health risk of these additives due to the water intake by humans. The major PAEs studied in this study include dibutyl phthalate (DBP), butyl benzyl phthalate (BBP), di-ethyl hexyl phthalate (DEHP), di-n-octyl phthalate (DNOP) and di-ethyl phthalate (DEP). The results indicated the presence of PAEs in trace amounts, which are not harmful to humans as they are present under the permissible levels.

Keywords

Phthalate, Endocrine disruptor, bottled water, daily intake, Hazard index

References

  1. Ye, X., et al. 2020. Microplastic acts as a vector for contaminants: the release behaviour of dibutyl phthalate from polyvinyl chloride pipe fragments in water phase. Env. Sci. Poll. Res.,27: 42082-42091.
  2. Prasad, B. 2021. Phthalate pollution: environmental fate and cumulative human exposure index using the multivariate analysis approach. Env. Sci. Process Impacts.23(3): 389-399.
  3. Cacho, J.I., et al. 2012. Determination of alkyl phenols and phthalate esters in vegetables and migration studies from their packages by means of stir bar sorptive extraction coupled to gas chromatography–mass spectrometry. J. Chromatogr. A., 1241: 21-27.
  4. Notardonato, I., et al. 2019. A method validation for simultaneous determination of phthalates and bisphenol A released from plastic water contai-ners. Appl. Sci.,9(14): 2945.
  5. Radke, E. G., et al. 2020. Phthalate exposure and neurodevelopment: A systematic review and meta-analysis of human epidemiological evidence. Env. Int.,137: 105408.
  6. US EPA. 2007. Municipal solid waste in the United States: 2007 facts and figures. U.S. Environmental Protection Agency, New York, USA.
  7. Dominguez-Morueco, N., S. Gonzalez-Alonso and Y. Valcarcel. 2014. Phthalate occurrence in rivers and tap water from central Spain. Sci. Total Env., 500-501: 139-146. doi: 10.1016/j.scitotenv.2014.08. 098.
  8. Zaater, M.F., Y.R. Tahboub and A.N. Al Sayyed. 2014. Determination of phthalates in Jordanian bottled water using GCMS and HPLCUV: Environmental study. J. Chromatogr. Sci., 2(5): 447–452. doi: 10.1093/chromsci/bmt059.
  9. Leitz, J., et al. 2009. Chemical analysis and risk assessment of diethyl phthalate in alcoholic beverages with special regard to unrecorded alcohol. PloS one.4(12): e8127.
  10. Yan, H., X. Cheng and B. Liu. 2011. Simultaneous determination of six phthalate esters in bottled milks using ultrasound-assisted dispersive liquid–liquid microextraction coupled with gas chromatography. J. Chromatogr. B. 879(25): 2507–2512. doi: 10.1 016/j.jchromb.2011.07.001.
  11. Zhu, L.P., et al. 2013. Rapid determination of 15 phthalates esters in vegetable juices by hollow fiberliquid phase microextraction coupled with gas chromatography mass spectrometry. China J. Anal. Chem., 41: 1019. doi: 10.3724/SP.J.1096.2013. 21053.
  12. Carrillo, J. D., et al. 2007. Determination of phthalates in wine by headspace solid-phase microex-traction followed by gas chromatography–mass spectrometry: fibre comparison and selection. J. Chromatogr. A. 1164 (1-2): 248–261. doi: 10.101 6/j.chroma.2007.06.059.
  13. Xu, J., P. Liang and T. Zhang. 2007. Dynamic liquid-phase microextraction of three phthalate esters from water samples and determination by gas chromatography. Anal. Chim. Acta. 597: 1–5. doi: 10.1016/j.aca.2007.06.047.
  14. Holadova, K., et al. 2006. Headspace solid-phase microextraction of phthalic acid esters from vegetable oil employing solvent based matrix modification. Anal. Chim. Acta. 582 (1): 24–33. doi: 10.1 016/j.aca.2006.09.005.
  15. Selvaraj, K. K., et al. 2016. Cumulative exposure and dietary risk assessment of phthalates in bottled water and bovine milk samples: A preliminary case study in Tamil Nadu, India. HERA.22(5):1166-1182.
  16. Das, M. T., P. Ghosh and I.S. Thakur. 2014. Intake estimates of phthalate esters for south Delhi population based on exposure media assessment. Env. Poll.,189: 118-125.
  17. Amritha, P. S., V. Vinod and P.B. Harathi. 2022. A critical review on extraction and analytical methods of phthalates in water and beverages. J. Chromatogr. A. 1675: 463175.
  18. Net, S., et al. 2015. Reliable quantification of phthalates in environmental matrices (air, water, sludge, sediment and soil): a review. Sci. Total Env.,515: 162-180.
  19. Rastkari, N. and R. Ahmadkhaniha. 2013. Magnetic solid-phase extraction based on magnetic multi-walled carbon nanotubes for the determination of phthalate monoesters in urine samples. J. Chromatogr. A. 1286: 22-28.
  20. Zare Jeddi, M., et al. 2015. Carcinogenic and non-carcinogenic assessment of phthalates exposure through consumption of bottled water during the storage time. Iranian J. Health Env.,8(1): 97-108.
  21. WHO. 2007. Weight-for-age percentiles tables references. World Health Organization, Geneva.
  22. EPA. 2011. Exposure factors handbook (EPA/600/R-09/052F). Prepared by the Office of Research and Development’s National Center for Environmental Assessments (NCEA).
  23. Kamrin, M.A. 2009. Phthalate risks, phthalate regulation and public health: a review. J. Toxicol. Env. Part B. 12(2): 157-174.
  24. Amiridou, D. and D. Voutsa. 2011. Alkylphenols and phthalates in bottled waters. J.  Hazard. Mater., 185(1): 281-286.
  25. Casajuana, N. and S. Lacorte. 2003. Presence and release of phthalic esters and other endocrine disrupting compounds in drinking water. Chromato-graphia.57: 649-655.
  26. Penalver, A., et al. 2000. Determination of phthalate esters in water samples by solid-phase micro-extraction and gas chromatography with mass spectrometric detection. Chromatogr. A. 872(1-2): 191-201.
  27. Prokùpková, G., et al. 2002. Development of a solid-phase microextraction method for the determination of phthalic acid esters in water. Anal. Chim. Acta.,457(2): 211-223.
  28. Prapatpong, P. and W. Kanchanamayoon. 2010. Determination of phthalate esters in drinking water using solid-phase extraction and gas chroma-tography.J. Appl. Sci. (Faisalabad). 10(17): 1987-1990.
  29. WHO and M.G. Candau. 1962. The work of WHO, 1961: annual report of the Director-General to the World Health Assembly and to the United Nations covering the period 1 October-31 December 1961. World Health Organization, Geneva. 
  30. Wormuth, M., et al. 2006. What are the sources of exposure to eight frequently used phthalic acid esters in Europeans? Risk Anal.,26(3): 803-824.
  31. Clark, K., I.T. Cousins and D. Mackay. 2003. Assessment of critical exposure pathways. Series anthropogenic compounds: phtalate esters. pp 227-262.
  32. Holadová, K., et al. 2007. Headspace solid-phase microextraction of phthalic acid esters from vegetable oil employing solvent based matrix modifi-cation. Anal. Chim. Acta. 582(1): 24-33.